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Common names: Gugulipid, Gum guggulu
Botanical name: Commiphora mukul
One study conducted in India showed that guggul increased the production of the thyroid hormone. Since this hormone is involved in the cells‘ breakdown of protein, fat, and carbohydrates, theoretically this herb should promote weight loss. More research is needed to prove whether or not this is the case.
Most of the research conducted on guggul has been in relation to its ability to lower cholesterol.
Coupled with exercise in a double-blind trial, a combination of guggul, phosphate salts, hydroxycitrate, and tyrosine has been shown to improve mood with a slight tendency to improve weight loss in overweight adults.1 Daily recommendations for guggul are typically based on the amount of guggulsterones in the extract. A common intake of guggulsterones is 25 mg three times per day. Most guggul extracts contain 5 to 10% guggulsterones and can be taken daily for 12 to 24 weeks.
Early studies with the crude oleoresin reported numerous side effects, including diarrhea, anorexia, abdominal pain, and skin rash. Modern extracts are more purified, and fewer side effects (e.g., mild abdominal discomfort) have been reported with long-term use. Rash was reported, however, as a fairly common side effect in one recent study.2 Guggul should be used with caution by people with liver disease and in cases of Crohn’s disease, ulcerative colitis, and diarrhea. A physician should be consulted before treating elevated cholesterol and triglycerides.
At the time of writing, there were no well-known drug interactions with guggul.
The mukul myrrh (Commiphora mukul) tree is a small, thorny plant distributed throughout India. Guggul and gum guggulu are the names given to a yellowish resin produced by the stem of the plant. This resin has been used historically and is also the source of modern extracts of guggul.
*Dieters and weight-management advocates may claim benefits for guggul based on their personal or professional experience. These are individual opinions and testimonials that may or may not be supported by controlled clinical studies or published scientific articles on guggul. For more complete and detailed information, including references and safety information, see Guggul as an herbal remedy.
1. Antonio J, Colker CM, Torina GC, et al. Effects of a standardized guggulsterone phosphate supplement on body composition in overweight adults: A pilot study. Curr Ther Res 1999;60:220–7.
2. Szapary PO, Wolfe ML, Bloedon LT, et al. Guggulipid for the treatment of hypercholesterolemia: an randomized controlled trial. JAMA 2003;290:765–72.
Copyright © 2007 Healthnotes, Inc. All rights reserved. www.healthnotes.com
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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.
