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Also indexed as: Carafate
Sucralfate is used to treat intestinal ulcers, and it is a type of drug known as a polysaccharide antipeptic.
Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.
 May Be Beneficial: Depletion or interference—The medication may deplete or interfere with the absorption or function of the nutrient. Taking these nutrients may help replenish them. | Calcium Phosphorus |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
| Adverse interaction | None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Calcium
Slight increases in blood calcium levels may occur in people taking sucralfate, which could be aggravated by calcium supplementation.1 Therefore, people taking calcium supplements and sucralfate should have their blood calcium levels monitored by their healthcare practitioner and may need to avoid calcium supplementation.
Phosphorus
People taking sucralfate may develop lower than normal blood levels of phosphorus.2 A 42-year-old woman who took sucralfate for two weeks experienced bone pain that was caused by low phosphorus levels. The bone pain disappeared after she stopped taking the drug and began supplementing with phosphorus.3 Individuals taking sucralfate should have their blood phosphorus levels monitored regularly by their healthcare practitioner and may need to take supplemental phosphorus.
1. Vucelic B, Hadzic N, Gragas J, Puretic Z. Changes in serum phosphorus, calcium, and alkaline phosphatase due to sucralfate. Int J Clin Pharmacol Ther Toxicol 1986;24:93–6.
2. Vucelic B, Hadzic N, Gragas J, Puretic Z. Changes in serum phosphorus, calcium, and alkaline phosphatase due to sucralfate. Int J Clin Pharmacol Ther Toxicol 1986;24:93–6.
3. Chines A, Pacifici R. Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature. Calcif Tissue Int 1990;47:291–5.
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Learn more about the authors of Using Medicines with Vitamins and Herbs
The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires February 2010.
