Highest Concentration of Active S,S Form. 30 Enteric-Coated Tablets in Foil Blister Pack. Jarrow Formulas® pharmaceutical grade, stabilized SAM-e 400 is a full 400 mg elemental SAM-e from 800 mg of SAM-e tosylate disulfate. SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

Contains More of the Active S,S Form
SAM-e (S-Adenosylmethionine) is a chiral molecule and therefore consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive.

Jarrow Formulas' SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.

SAM-e is an amino acid derivative that has been clinically proven to benefit brain, joint and liver function. Found in all living cells, SAM-e is also called "activated" methionine (an essential amino acid) since it is formed by the combining of ATP with methionine. SAM-e has undergone dozens of trials involving thousands of patients. Researchers studying the beneficial effects of SAM-e have identified the following benefits of SAM-e:

Joint Strength
SAM-e supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e metabolites.

Brain Metabolism
SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-dopa, dopamine and related hormones, epinephrine and phosphatidylcholine (a component of lecithin).

Longevity
Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process. Proper methylation through substances such as SAM-e positively influences longevity.

Liver
SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances important for liver function.

Suitable for vegetarians.

Take 1 tablet per day on an empty stomach, or as directed by your qualified health consultant.

Individuals using prescribed medications such as antidepressants, including Serotonin Re-Uptake Inhibitors and MAO Inhibitors should consult a physician before using. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e.

Jarrow Formulas SAM-e 400 is foil blister-packed to maximize stability and safety. Do not use if outer seal of blister pack is broken. Full potency 400 mg elemental SAM-e is derived from 800 mg of tosylate disulfate SAM-e.

Store in a cool, dry place. Keep out of the reach of children.

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.