Vitamin E is an antioxidant that protects cell membranes and other fat-soluble parts of the body, such as low-density lipoprotein (LDL; "bad" cholesterol), from damage.

Several studies, including two double-blind trials, have reported that 400 to 800 IU of natural vitamin E per day reduces the risk of heart attacks. Other recent double-blind trials have found either limited benefit or no benefit at all from supplementation with synthetic vitamin E. One of the negative trials used 400 IU of natural vitamin E, a similar amount and form to previous successful trials. In attempting to make sense of these apparently inconsistent findings, the following is clear: less than 400 IU of synthetic vitamin E, even when taken for years, does not protect against heart disease. Whether 400 to 800 IU of natural vitamin E is, or is not, protective remains unclear.

Vitamin E also plays some role in the body's ability to process glucose. Some, but not all, trials suggest that vitamin E supplementation may eventually prove to be helpful in the prevention and treatment of diabetes.

In the last ten years, the functions of vitamin E in the cell have been further clarified. In addition to its antioxidant functions, vitamin E is now known to act through other mechanisms, including direct effects on inflammation, blood cell regulation, connective tissue growth, and genetic control of cell division.

These vitamin E supplements are non-esterified, free tocopherols that are more potent anti-oxidants than the esterified forms (tocopheryl acetate or tocopheryl succinate).
E-400 Sesame contains sesame oil which provides a source of T factors, sometimes called Vitamin T. The "sesame seed factor" is helpful in normalizing blood coagulation and in alleviating anemia due to limited formation of blood platelets and in the formation of T lymphocytes. Acts like a natural blood thinner. Improves the general condition of the platelets by making them slippery or less adhesive. Also added to enhance absorption.