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Best Fully Active B12 provides MethylCobalamin, the most biochemically active form of vitamin B12. Various inherited and lifestyle factors contribute to vitamin B12 deficiencies that impair such fundamental life processes as recycling of homocysteine, a potentially toxic metabolite; nerve cell signaling; mood and memory management; and healthy gene regulation (epigenetics), from pregnancy through old age. Best Fully Active B12 is vitamin B12 at its best.