CoQ10
Three sizes available:

CoQ10 - 60 softgels, 30 mg. - $24.95, $10.95 you save 56%
CoQ10 - 60 softgels, 60 mg. - $39.95, $17.95 you save 55%
CoQ10 - 60 softgels, 100 mg. - $69.95, $28.90 you save 59%

NEW! CoQ10 From NSI! with COQsol™ formulation

Description: Coenzyme Q10 is a necessary substance for normal heart function.* CoQ10 is vital for cellular energy production and is a powerful antioxidant and free radical scavenger.* Softgel delivery is ideal for CoQ10 absorption and utilization because of its solubility in oil. (see study chart and data below).

Coenzyme Q10 appears throughout the human body. It aids metabolic reactions such as the transformation of food into ATP, the energy used by the body. Cell mitochondria (the part of cells where energy is produced) show the greatest concentration of coenzyme Q10 in the body. Similarly, organs that contain higher amounts of mitochondria per cell are those which overall have the greatest amount of coenzyme Q10. These include the heart and the liver.

Coenzyme Q10 deficiency appears to be caused more by the body’s inability to synthesize the nutrient than by a lack of the enzyme in the diet. Low blood levels are often associated with poor heart function and may be associated with other adverse affects in the body.* Low levels also appear more common in older people.

Recommended Dosage: 30 to 100 mg daily. For certain individuals, higher dosage may be appropriate. Coenzyme Q10 appears to absorb best with meals.

Absorbtion Study Shows Softgel CoQsol™ is Superior to Dry CoQ10 by 273%!

Greater Bioavailabilty -- Basal Blood
CoQ10 Levels Increase 265%
For CoQ10sol™ vs. Dry CoQ10 of 180%.

Big Increase in Experienced Energy Levels --83% of CoQsol™ vs. 30% of Dry CoQ10.

Benefits of NSI CoQ10

• Superior Absorption - Almost three times higher than dry form.
• Superior Bioavailability
• More Energy Experienced
• Easy to Swallow Softgels
• Exceptional Savings

More information about CoQ10 and its benefits:

Since the discovery of Coenzyme Q10 (CoQ10), investigative inquiry into its clinical value has led to widespread use and substantiation of its benefits to human health and disease. Effective in treating heart diseases, increasing energy levels, enhancing the immune system, reversing gum disease, providing antioxidant activity, and preventing certain side effects of common drugs, CoQ10 is one of the most thoroughly researched nutraceuticals on the market today. The first small clinical inquiry using Coenzyme Q dates back to 1965, but it was not until 1974 that pure CoQ10 was generated industrially in large enough quantities for large trials in humans.

CoQ10 was first isolated from beef heart mitochondria in 1957 and its exact structure was later eludicated by classical organic chemistry techniques in 1958. It was given the name Ubiquinone because it is ubiquitous in nature. The existence of ubiquinone is fundamental to all forms of life: it is found in the mitochondria of animals, as plastoquinone in the chlorophyll of plants and as menaquinone in bacteria. Many analogs of ubiquinone exist (CoQ10-CoQ12), but CoQ10 is of the most importance in human biochemistry.

CoQ10 is a member of the quinone family, composed of a “quinone” nucleus in which two of the four hydrogen atoms are each replaced by a methoxy group (MeO), one by a methyl group (Me) and the fourth is replaced by a chain of ten isoprene units. This is why it is designated Q10. CoQ10 is synthesized endogenously and distributed to bodily tissues where it is needed. Within the body, it is located mostly in skeletal and cardiac muscle tissue, liver, kidney, and reproductive organs: all areas of high physiological activity.

CoQ10 resides within the mitochondria of cells whereby life-sustaining, energy-producing processes take place. In the mitochondria, the “powerhouse” of the cell, a series of complex biochemical reactions take place. These reactions, known as cellular respiration, result in the formation of energy: adenosine triphosphate (ATP). CoQ10 is a vital component of this energy generating process at the cellular level: it is a true coenzyme. Enzymes, (biological catalysts), often bring about chemical change within the body. CoQ10 works in the mitochondrial membrane as an electron acceptor/proton donor, facilitating the process of energy production. The body must continually generate energy to support life from these minute power plants within every cell. Hence, the presence of CoQ10 in the body is fundamental to sustaining life. The relationship of CoQ10 to the intricate mechanism of cellular energy production brings about broader understanding of why CoQ10 deficiencies may lead to serious malfunction of biochemical systems. It is generally understood that many diseases result from mitochondrial dysfunction.

BioAvailability
An abundance of data considers the uptake and tissue distribution of CoQ10 in animal models. It was found in both rats and rabbits, CoQ10 is absorbed without conversion primarily through the lymphatic system after oral administration. The distribution of CoQ10, 4 hours after oral administration in rats, was shown to be particularly high in tissues having high metabolic activity: the lungs, heart, testes, liver and kidney. This pattern of CoQ10 distribution is consistent in humans with minor differences in peak plasma levels upon supplementation. Human serum concentrations of CoQ10 reach a peak at approximately 6 hours after ingestion of supplements or meals abundant in CoQ10.

It is known that there is about 1.0 µg/ml of CoQ10 present in human plasma under normal conditions. However, in the case of various disease states such as heart failure, chronic fatigue, cancer, serum levels are considerably lower. More importantly, the most recent clinical research suggests that serum CoQ10 levels should reach at least 2.5-3.0 µg/ml in order to be of therapeutic value.

There has been some debate on the type of formulation that should be used to provide the best absorption of CoQ10 from the gut. Various methods have been tested to introduce CoQ10 in micellar form via the use of additives such as lecithin, polysorbate 80 and other surfactants. Historically, the most promising vehicle for CoQ10 absorption has been the use of a lipophilic medium such as a natural oil, for example, soy bean oil or rice bran oil.