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Diabetes
Description: A metabolic condition caused by the body’s inability to produce adequate amounts of insulin.

Cause: Unknown. Type 2 may be caused by obesity.

Useful Supplements: Alpha-Lipoic Acid, Carnitine, Chromium, Coenzyme Q10, Evening Primrose Oil, Inositol, Magnesium, Taurine, Vanadium, Vitamin B6, Vitamin B12, Biotin, Vitamin C, Vitamin E, Zinc.

Useful Herbs: Aloe Vera, Asian ginseng, Bitter Melon, Gymnema.

Further information: Diabetes is a metabolic disorder which is caused by the body’s inability to produce adequate insulin supplies. This results in high blood sugar, which can cause dizziness, visual problems, and heart conditions.

There are two main types of diabetes. Type 1 diabetes is when the pancreas stops producing insulin (the chemical needed by the body to process foods and sugars into energy). Type 1 diabetes (also called Juvenile Diabetes) accounts for about 10% of all diagnosed diabetes, and is treated via insulin injections. In addition, a low-sugar diet is recommended.

Type 2 diabetes is caused by a number of factors: pancreas not producing enough insulin, liver producing too much glucose (sugar), or body cells not being receptive to insulin. This type of diabetes is quite common, and is usually treated by change in diet and lifestyle.

Diabetes is a very common disease. It becomes more common with age. Risk factors include people with a family history of diabetes, those who are overweight, and women who have suffered from gestational diabetes (diabetes which occurs during, and is related to, pregnancy).

The cause of diabetes is unknown. Certain factors appear to increase one’s susceptibility to it, however. In addition to the risk factors listed above, environmental events (such as a virus, a vaccination, or shock) may be the trigger for Type 1 diabetes. Type 2 diabetes appears to be more related to obesity and inactivity.

While eating large amounts of sugar does NOT cause diabetes, it can lead to obesity, which can in turn cause type 2 diabetes.

Eating natural, non-processed foods is helpful in the day-to-day treatment of diabetes, and is recommended even with insulin treatment.

Some foods appear to be especially helpful in the prevention and treatment of diabetes. A vegetarian diet seems to help prevent the onset of Type 2 diabetes.1 Completely vegan diets appear even more effective, and even help to reverse some of the problems related to diabetes.2

Part of the effectiveness of a vegetarian or vegan diet in the treatment of diabetes appears to be due to the low protein content of such diets. Lower protein intake appears to lower the risk of kidney damage caused by diabetes3 and to help improve glucose tolerance.4

High fiber foods – including fruit pectin5 and oat bran6 – improve glucose tolerance. Monounsaturated fats have also been shown to be effective in the treatment of diabetes.7

Fish appears to offer some protection against the onset of diabetes.8

One food’s effect on diabetes has been the cause of much discussion in the past several years: dairy. Countries with high milk consumption have higher incidence of Type 2 diabetes.9 Many studies have shown that children who develop Type 1 diabetes at an early age also started drinking milk early.10 It may be that milk intolerances trigger the onset of diabetes11 but this is not certain.12

The most effective way to avoid Type 2 diabetes is through exercise and weight management. While excess weight does not prevent insulin formation13, it does appear to make the body less sensitive to insulin and its effects.14 Excess weight can put the body into a pre-diabetic state15 from which diabetes can quickly occur. Weight loss will reverse this situation, however.16

Smoking diabetics are at higher risk for heart disease17, kidney damage18, and other complications. In addition, smokers have a higher rate of diabetes than the general population.19

The following nutrients and herbs may be effective in the prevention and treatment of diabetes:

The antioxidant Alpha-Lipoic Acid, taken in a dose of 600 mg daily, has been shown to help improve nerve damage and reduce pain in diabetics.20

Carnitine is used by the body to help turn fat into energy. Taken in a dose of 1 mg per 2.2 pounds of body weight, it can drastically reduce cholesterol and triglyceride levels in as little as ten days.21 Higher doses (1 gram daily) may help reduce nerve damage caused by diabetics.22

Chromium appears to improve glucose tolerance in animals.23 In humans, it appears to increase sensitivity to insulin,24 and to improve glucose processing in people with prediabetic glucose intolerance25 or gestational diabetes.26 Recommended dosage is anything from 200 mcg to 1000 mcg daily.27

Coenzyme Q10, used for carbohydrate processing, often is effective in helping diabetics to lower their blood sugar levels.28

Evening Primrose Oil supplements appear to help reverse diabetic nerve damage and decrease pain in both type 1 and type 2 diabetics.29

Inositol can help reverse nerve abnormalities related to diabetes.30 A dose of 500 mg twice daily appears most effective.

Low Magnesium levels are very common in patients with diabetes.31 Magnesium supplementation appears to improve insulin production in Type 2 diabetics,32 and to decrease the amount of injected insulin needed by Type 1 diabetics.33

The American Diabetes Association has acknowledged the "strong associations...between Magnesium deficiency and insulin resistance".34 Daily supplementation of 300 to 400 mg is recommended.

The amino acid Taurine often is deficient in Type 1 diabetics. Supplementing with 1.5 grams daily helps to replenish the body’s supply and to correct blood viscosity problems caused by the deficiency.35

Vanadium, taken as vanadyl sulfate, may help improve glucose control in Type 2 diabetics.36 However, it usually needs to be taken in a high quantity to offer these effects, and its safety at these levels is untested.

Many diabetics, especially those with nerve damage,37 have low blood levels of Vitamin B6.38 B6 supplements appear especially effective in treatment of gestational diabetes.39

Vitamin B12, taken orally (up to 500 mcg three times daily) or intravenously, reduces nerve damage caused by diabetes.40

Biotin is another B vitamin needed in the production of glucose. Supplementation of biotin has been shown to reduce fasting glucose levels in diabetics by 50%.41 Biotin may also help to reduce pain caused by diabetes-related nerve damage.42

Vitamin C levels have measured low in many diabetics.43 It is suspected that Vitamin C helps the body to reduce glycolysation,44 which is an abnormal attachment of sugars to proteins. It also lowers accumulation of the sugar sorbitol,45 which can damage eyes and kidneys.

Low Vitamin E is also found in many diabetics.46 Taking a supplement appears to improve glucose tolerance in both diabetics47 and non-diabetics.48 A dose of approximately 900 IU daily, taken for at least three months, is generally needed before any benefits are seen. Vitamin E also may be effective in reducing glycosylation.49

Zinc deficiencies are common in Type 1 diabetics.50 Zinc supplements have been shown to lower blood sugar levels in these patients.51 However, Type 1 diabetics should not supplement with Zinc without consulting their health professionals, as supplements may cause an increase in glycosylation.
Type 2 diabetics also have low Zinc levels.
52 They are usually able to take supplements of up to 25 mg daily without any adverse effects.

Aloe Vera juice appears to help lower blood sugar in Type 2 diabetes. 1 tablespoon twice daily appears highly effective in improving the effectiveness of blood sugar lowering medications.53

Asian ginseng is traditionally used in Chinese medicine as a treatment for diabetes. It encourages the pancreas to release insulin and increase the number of insulin receptors.54 It also appears to directly lower blood sugar,55 and helps improve energy levels in Type 2 diabetics.56 It should not be taken by patients with high blood pressure.

Preliminary studies suggest that Bitter Melon – eaten whole,57 as a juice,58 or in extract form59 -- may improve blood sugar control in Type 2 diabetics.

Gymnema helps the pancreas to increase insulin production for Type 2 diabetics. No controlled studies have been done. However preliminary research suggests that 400 mg taken daily can reduce the need for oral medications by Type 2 diabetics.60 It may also decrease the amount of insulin needed by Type 1 diabetics.61 These changes should not be made without the assistance of a health care professional.

References:

1Snowdon DA, Phillips RL. Does a vegetarian diet reduce the occurrence of diabetes? Am J Publ Health 1985;75:507–12.
2Crane MG, Sample CJ. Regression of diabetic neuropathy with vegan diet. Am J Clin Nutr 1988;48:926 (abstract #P28).
3Cohen D, Dodds R, Viberti G. Effect of protein restriction in insulin dependent diabetics at risk of nephropathy. BMJ 1987;294:795–98.
4Gin H, Aparicio M, Potauz L, et al. Low-protein, low-phosphorus diet and tissue insulin sensitivity in sinulin-dependent diabetic patients with chronic renal failure. Nephron 1991;57:411–5.
5Schwartz SE, Levine RA, Weinstock RS, et al. Sustained pectin ingestion: effect on gastric emptying and glucose tolerance in non-insulin-dependent diabetic patients. Am J Clin Nutr 1988;48:1413–7.
6Hallfrisch J, Scholfield DJ, Behall KM. Diets containing soluble oat extracts improve glucose and insulin responses of moderately hypercholesterolemic men and women. Am J Clin Nutr 1995;61:379–84.
7Garg A, Bananome A, Grundy SM, et al. Comparison of a high-carbohydrate diet with a high-monounsaturated-fat diet in patients with non-insulin dependent diabetes mellitus. N Engl J Med 1988;319:829–34.
8Feskens EJM, Bowles CH, Kromhout D. Inverse association between fish intake and risk of glucose intolerance in normoglycemic elderly men and women. Diabetes Care 1991;14:935–41.
9Dahl-Jorgensen K, Joner G, Hanssen KF. Relationship between cows’ milk consumption and incidence of IDDM in childhood. Diabetes Care 1991;14:1081–3.
10Gerstein H. Cow milk exposure and type I diabetes mellitus. Diabetes Care 1994;17:13–9.
11Karajalainen J, Martin JM, Knip M, et al. A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Engl J Med 1992;327:302–7.
12Atkinson, MA, Bowman MA, Kao K-J, et al. Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes. N Engl J Med 1993;329:1853–8.
13Casassus P, Fontbonne A, Thibult N, et al. Upper-body fat distribution: a hyperinsulinemia-independent predictor of coronary heart disease mortality. Arterioscler Throm 1992;1387–92.
14Karter AJ, Mayer-Davis EJ, Selby JV, et al. Insulin sensitivity and abdominal obesity in African-American, Hispanic, and non-Hispanic white men and women. Diabetes 1996;45:1547–55.
15Park KS, Hree BD, Lee K-U, et al. Intra-abdominal fat is associated with decreased insulin sensitivity in healthy young men. Metabol 1991;40:600–3.
16Long SD, Swanson MS, O’Brien K, et al. Weight loss in severely obese subjects prevents the progression of impaired glucose tolerance to type II diabetes. Diabetes Care 1994;17:372.
17Scala C, LaPorte RE, Dorman JS, et al. Insulin-dependent diabetes mellitus mortality—the risk of cigarette smoking. Circulation 1990;82:37–43.
18Stegmayr B, Lithner F. Tobacco and end stage diabetic nephropathy. BMJ1987;295:581–2.
19Rimm EB, Manson JE, Stampfer MJ, et al. Cigarette smoking and the risk of diabetes in women. Am J Public Health 1993;83:211–4.
20Packer L, Witt EH, Tartschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Radical Biol Med 1995;19:227–50.
21Abdel-Aziz MT, Abdou MS, Soliman K, et al. Effect of carnitine on blood lipid pattern in diabetic patients. Nutr Rep Internat 1984;29:1071–79.
22Onofrj M, Fulgente T, Mechionda D, et al. L-acetylcarnitine as a new therapeutic approach for peripheral neuropathies with pain. Int J Clin Pharmacol Res 1995;15:9–15.
23Schroeder HA. Serum cholesterol and glucose levels in rats fed refined and less refined sugars and chromium. J Nutr 1969;97:237–42.
24Gaby AR, Wright JV. Diabetes. In Nutritional Therapy in Medical Practice: Reference Manual and Study Guide. Kent, WA: Wright/Gaby Seminars, 1996, 54–64 [review].
25Anderson RA, Polansky MM, Bryden NA, Canary JJ. Supplemental-chromium effects on glucose, insulin, glucagon, and urinary chromium losses in subjects consuming controlled low-chromium diets. Am J Clin Nutr 1991;54:909–16.
26Jovanovic-Pterson L, Gutierrez M, Peterson CM. Chromium supplementation for gestational diabetic women improves glucose tolerance and decreases hyperinsulinemia. J Am Coll Nutr 1995;14:530 [abstract #26].
27Lee NA, Reasner CA. Beneficial effect of chromium supplementation on serum triglyceride levels in NIDDM. Diabetes Care 1994;17:1449–52.
28Shigeta Y, Izumi K, Abe H. Effect of coenzyme Q7 treatment on blood sugar and ketone bodies of diabetics. J Vitaminology 1966;12:293–98.
29Reichert R. Evening primrose oil and diabetic neuropathy. Quarterly Rev Natural Med Summer 1995:129–33 [review].
30Salway JG, Whitehead L, Finnegan JA, et al. Effect of myo-inositol on peripheral-nerve function in diabetes. Lancet 1978;II:1282–84.
31Paolisso G, Scheen A, D’Onofrio FD, Lefebvre P. Magnesium and glucose homeostasis. Diabetologia 1990;33:511–4 [review].
32Paolisso G, Sgambato S, Pizza G, et al. Improved insulin response and action by chronic magnesium administration in aged NIDDM subjects. Diabetes Care 1989;12:265–69.
33Sjorgren A, Floren CH, Nilsson A. Oral administration of magnesium hydroxide to subjects with insulin dependent diabetes mellitus. Magnesium 1988;121:16–20.
34Nakamura T, Higashi A, Nishiyama S, et al. Kinetics of zinc status in children with IDDM. Diabetes Care 1991;14:553–57.
35Franconi F, Bennardini F, Mattana A, et al. Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am J Clin Nutr 1995;61:1115–19.
36Halberstam M, Cohen N, Shlimovich P, et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996;45:659–66.
37McCann VJ, Davis RE. Serum pyridoxal concentrations in patients with diabetic neuropathy. Austral NZ Med 1978;8:259–61.
38Davis RE, Calder JS, Curnow DH. Serum pyridoxal and folate concentrations in diabetics. Pathol 1976;8:151–6.
39Coelingh HJT, Schreurs WHP. Improvement of oral glucose tolerance in gestational diabetes by pyridoxine. BMJ 1975;3:13–15.
40Yamane K, Usui T, Yamamoto T, et al. Clinical efficacy of intravenous plus oral mecobalamin in patients with peripheral neuropathy using vibration perception thresholds as an indicator of improvement. Curr Ther Res 1995;56:656–70 [review].
41Coggeshall JC, Heggers JP, Robson MC, Baker H. Biotin status and plasma glucose in diabetics. Ann NY Acad Sci 1985;447:389–92.
42Koutsikos D, Agroyannis B, Tzanatos-Exarchou H. Biotin for diabetic peripheral neuropathy. Biomed Pharmacother 1990;44:511–14.
43Cunningham JJ, Ellis SL, McVeigh KL, et al. Reduced mononuclear leukocyte ascorbic acid content in adults with insulin-dependent diabetes mellitus consuming adequate dietary vitamin C. Metabol 1991;40:146–49.
44
45Will JC, Tyers T. Does diabetes mellitus increase the requirement for vitamin C? Nutr Rev 1996;54:193–202 [review].
46Salonen JT, Nyssonen K, Tuomainen T-P, et al. Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men. BMJ 1995;311:1124–27.
47Paolisso G, D’Amore A, Giugliano D, et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin dependent diabetic patients. Am J Clin Nutr 1993;57:650–56.
48Paolisso G, Gambardella A, Galzerano D, et al. Antioxidants in adipose tissue and risk of myocardial infarction. Lancet 1994;343:596 [letter].
49Duntas L, Kemmer TP, Vorberg B, Scherbaum W. Administration of d-alpha-tocopherol in patients with insulin-dependent diabetes mellitus. Curr Ther Res 1996;57:682–90.
50Mcchegiani E, Boemi M, Fumelli P, Fabris N. Zinc-dependent low thymic hormone level in type I diabetes. Diabetes 1989;12:932–37.
51Rao KVR, Seshiah V, Kumar TV. Effect of zinc sulfate therapy on control and lipids in type I diabetes. JAPI 1987;35:52 [abstract].
52Pidduck HG, Wren PJJ, Price Evans DA. Hyperzincuria of diabetes mellitus and possible genetic implications of this observation. Diabetes 1970;19:240–47.
53Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L juice II. Clinical trial in diabetes mellitus patients in combination with glibdenclamide. Phytomed 1996;3:245–48.
54Suzuki Y, Hikino H. Mechanisms of hypoglycemic activity of panaxans A and B, glycans of Panax gisneng roots: Effects on plasma levels, secretion, sensitivity and binding of insulin in mice. Phytother Res 1989;3:20–24.
55Waki I, Kyo H, et al. Effects of a hypoglycemic component of ginseng radix on insulin biosynthesis in normal and diabetic animals. J Pharm Dyn 1982;5:547–54.
56Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in non-insulin-dependent diabetic patients. Diabetes Care 1995;18:1373–75.
57Leatherdale BA, Panesar RK, Singh G, et al. Improvement of glucose tolerance due to Momordica charantia (karela). BMJ 1981;282:1823–24.
58Welihinda J, Karunanaya E, Sheriff MHB, Jayasinghe K. Effect of Momardica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharm 1986;17:277–82.
59Srivastava Y, Venkatakrishna-bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285–89.
60Baskaran K, Ahmath BK, Shanmugasundaram KR, Shanmugasundaram ERB. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295–305.
61Shanmugasundaram ERB, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281–94.

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