| Description: Elevation of serum cholesterol to above 200 mg/dl. Cause: Diet, genetic predisposition. Useful Supplements: Beta-sitosterol, Calcium, Carnitine, Chromium, Folic Acid, Pantethine, Royal Jelly, Vitamin B3, Vitamin B6, Vitamin B12, Vitamin C. Useful Herbs: Garlic, Guggul, Wild Yam. Further information: Cholesterol is a blood lipid, a fatty substance that is found in all parts of the body. When the concentration of cholesterol in the blood is too high, many problems, including heart disease, can occur. Cholesterol is needed by the body in some quantity. It is manufactured by the liver and responsible for functions such as the production of hormones, bile acid, and Vitamin D. About one quarter of American adults have elevated cholesterol levels. Cholesterol is measured based on its concentration in the blood stream. A total cholesterol level of under 200 mg/dl is desired, as levels in this range are associated with the least risk of heart disease. The most important lifestyle change to help lower cholesterol is to avoid foods that are high in saturated fats.1 Avoiding most dairy products can also help.2 Specific foods that may help lower cholesterol include yogurt3, fiber-rich foods,4 Garlic,5 soy products,6 olive oil,7 and Fish Oil.8 Foods that are especially dangerous for increasing cholesterol levels include alcohol,9 coffee,10 foods containing trans-fatty acids (including margarine).11 Vegetarian12 and vegan13 diets are associated with the lowest cholesterol levels. Eating several small meals rather than two or three large meals daily appears to be connected with lower cholesterol levels.14 Exercise, even walking,15 can help lower cholesterol levels.16 Since high cholesterol and heart disease often occur together, it is important to talk to a health professional before beginning any exercise regimen. The following supplements and herbs may be helpful in the treatment of high cholesterol: Beta-sitosterol reduces blood cholesterol levels.17 It appears that Beta-sitosterol actually prevents the bodys absorption of cholesterol.18 Calcium binds fats and prevents their absorption by the body.19 Possibly as a result of this, Calcium also reduces cholesterol levels.20 Carnitine reduces serum cholesterol21 while increasing HDL levels.22 Chromium supplementation reduces LDL23 and increases HDL24 levels. Pantethine appears to significantly lower cholesterol levels while increasing levels of HDL ("good cholesterol").25 Royal Jelly can counteract some of the cholesterol-elevating effects of nicotine.26 It also lowers general cholesterol levels.27 Several B vitamins B6, B12, and Folic Acid decrease the rate at which LDL is oxidized (damaged).28 They also appear to lower heart disease risk overall. Vitamin B3 (niacin), when taken in high doses, lowers cholesterol.29 However, since it can be toxic in high doses, many natural doctors suggest the use of Inositol hexaniacinate instead. Vitamin C supplementation can cause cholesterol levels to drop.30 Garlic has been widely studies for its cholesterol-lowering properties.31 Taken for four months, it can reduce cholesterol levels by about 10%.32 Guggul has been found to reduce cholesterol levels by as much as 17%,33 making it as effective as the prescription treatment clofibrate.34 Wild Yam, taken in a dose of 2 to 3 ml several times daily, has been shown to increase HDL levels.35 References: 1Kromhout D, Menotti A, Bloemberg B, et al. Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: the Seven Countries Study. Prev Med 1995;24:30815. 2Ornish D, Brown SE, Scherwitz LW, et al. Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial. Lancet 1990;336:12933. 3Hepner G, Fried R, St Jeor S, et al. Hypocholesterolemic effect of yogurt and milk. Am J Clin Nutr 1979;1924. 4Rimm EB, Ascherio A, Giovannucci E, et al. Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men. JAMA 1996;275:44751. 5Warshafsky S, Kamer RS, Sivak SL. Effect of garlic on total serum cholesterola meta-analysis. Ann Intern Med 1993;119:599605. 6Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 1995;3333:27682. 7 8Albert CM, Manson JE, ODonnoell C, et al. Fish consumption and the risk of sudden death in the Physicians Health Study. Circulation 1996;94 (suppl 1):I-578 (asbtract #3382). 9Hein HO, Suadicani P, Gyntelberg F. Alcohol consumption, serum low density lipoprotein cholesterol concentration, and risk of ischaemic heart disease: six year follow up in the Copenhagen male study. BMJ 1996;73641. 10Nygird O, Refsum H, Velanb PM, et al. Coffee consumption and plasma total homocysteine: The hordaland homocysteine study. Am J Clin Nutr 1997;65:13643 11Willett WC, Stampfer MJ, Manson JE, et al. Intake of trans fatty acids and risk of coronary heart disease among women. Lancet 1993;341:5815. 12Thorogood M, Carter R, Benfield L, et al. Plasma lipids and lipoprotein cholesterol concentrations in people with different diets in Britain. BMJ 1987;295:3513. 13Burr ML, Sweetnam PM. Vegetarianism, dietary fiber and mortality. Am J Clin Nutr 1982;36:8737. 14Edelstein SL, Barrett-Connor EL, Wingard DL, Cohn BA. Increased meal frequency associated with decreased cholesterol concentrations; Rancho Bernardo, CA, 1984-1987. Am J Clin Nutr 1992;55:6649. 15Duncan JJ, Gordon NF, Scott CB. Women walking for health and fitnesshow much is enough? JAMA 1991;266:329599. 16Reaven PD, McPhillips JB, Barrett-Connor EL, Criqui MH. Leisure time exercise and lipid and lipoprotein levels in an older population. J Am Geriatr Soc 1990;38:84754. 17Pelletier X, Belbraouet S, Mirabel D, et al. A diet moderately enriched in phytosterols lowers plasma cholesterol concentrations in normocholesterolemic humans. Ann Nutr Metab 1995;39:29195. 18Grundy SM, Ahrens EH Jr, Davignon J. The interaction of cholesterol absorption and cholesterol synthesis in man. J Lipid Res 1969;10:30415 (review). 19Denke MA, Fox MM, Schulte MC. Short-term dietary calcium fortification increases fecal saturated fat content and reduces serum lipids in men. J Nutr 1993;123:104753. 20Yacowitz H, Fleischman AI, Bierenbaum ML. Effects of oral calcium upon serum lipids in man. BMJ 1965;1:13524. 21Pola P, Savi L, Grilli M, et al. Carnitine in the therapy of dyslipidemic patients. Curr Ther Res 1980;27:20816. 22Rossi CS, Siliprandi N. Effect of carnitine on serum HDL-cholesterol: report of two cases. Johns Hopkins Med J 1982;150:514. 23Press RI, Geller J, Evans GW. The effect of chromium picolinate on serum cholesterol and apolipoprotein fractions in human subjects. West J Med 1990;152:415. 24Roeback JR, Hla KM, Chambless LE, Fletcher RH. Effects of chromium supplementation on serum high-density lipoprotein cholesterol levels in men taking beta-blockers. Ann Intern Med 1991;115:91724. 25Miccoli R, Marchetti P, Sampietro T, et al. Effects of pantethine on lipids and apolipoproteins in hypercholesterolemic diabetic and non diabetic patients. Curr Ther Res 1984;36:5459. 26Abou-Hozaifa BM, Badr El-Din NK. Royal jelly, a possible agent to reduce the nicotine-induced atherogenic lipoprotein profile. Saudi Med J 1995;16:33742. 27Vittek J. Effect of royal jelly on serum lipids in experimental animals and humans with atherosclerosis. Experientia 1995;51:92735 (summary). 28Heinecke JW, Rosen H, Suzuki LA, Chait A. The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells. Biol Chem 1987;262:1009810103. 29Brown WV. Niacin for lipid disorders. Postgrad Med 1995;98:18593. 30Simon JA. Vitamin C and cardiovascular disease: a review. J Am Coll Nutr 1992;11:10727. 31Silagy C, Neil A. Garlic as a lipid-lowering agenta meta-analysis. J R Coll Physicians London 1994;28:3945. 32Holzgartner J, Schmidt U, Kuhn U. Comparison of the efficacy of a garlic preparation vs. bezafibrate. Arzneim-Forsch Drug Res 1992;42:14737. 33Agarwal RC, Singh SP, Saran RK, et al. Clinical trial of gugulipid new hypolipidemic agent of plant origin in primary hyperlipidemia. Indian J Med Res 1986;84:62634. 34Nityanand S, Srivastava JS, Asthana OP. Clinical trials with GugulipidA new hypolipidemic agent. J Assoc Phys India 1989; 37:3238. 35Araghiniknam M, Chung S, Nelson-White T, et al. Antioxidant activity of dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sci 1996;11:14757.
|