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Chromium is a trace element which may work closely with insulin to help facillatate the the uptake of glucose into cells. Chromax II™ brand of chromium picolinate is a compound of trivalent chromium and picolinic acid. Chromium Picolinate is patented by the U.S.D.A. and licensed exclusively to Nutrition 21. Licensed under U.S. Patent Re. 33,988.