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Evening Primrose Oil
Description: Evening Primrose Oil (EPO) is a source of the essential fatty acid gamma-linolenic (GLA). Fatty acids are needed by the body to produce prostaglandins, whose functions include metabolizing cholesterol, dilating blood vessels, and preparing the pregnant body for labor.
EPO has been shown effective as an anti-inflammatory in patients with rheumatoid arthritis.
1 Its primary component, GLA, also appears to have anti-cancer potential.2
Linoleic acid, commonly found in nuts, seeds, and vegetable oils, is normally converted by the body into gamma-linolenic acid, and then into prostaglandin. However, many things can interfere with this process: heart disease, age, hydrogenated oils, diabetes, and deficiency of Vitamin C, B vitamins, Magnesium, and Zinc. In these cases, supplementation with EPO or another source of GLA is highly recommended.
3
A prostaglandin deficiency is often found in patients as mentioned above, as well as with premenstrual syndrome,
4 eczema,5 and other skin conditions.6

Natural Sources: Black current seed oil, borage oil.

Useful in treatment of: atherosclerosis, Attention Deficit/Hyperactivity Disorder, Fibrocystic Breast Condition, Irritable Bowel Syndrome (IBS), pregnancy and post partum, Premenstrual Syndrome (PMS), rheumatoid arthritis.

Recommended Dosage: 3000 to 6000 mg daily.

Contraindications: Should not be taken by patients with epilepsy.

References:

1Joe LA, Hart LL. Evening primrose oil in rheumatoid arthritis. Ann Pharmacother 1993;27:1475–77 [review].
2McIllmurray MB, Turkie W. Controlled trial of gamma linolenic in Duke’s C colorectal cancer. BMJ 1987;294:1260.
3Horrobin DF. The importance of gamma-linolenic acid and prostaglandin E1 in human nutrition and medicine. J Holistic Med 1981;3:118–39.
4Horrobin DF, Manku M, Brush M, et al. Abnormalities in plasma essential fatty acid levels in women with pre-menstrual syndrome and with non-malignant breast disease. J Nutr Med 1991;2:259–64.
5Manku MS, Horrobin, DF, Morse NL, et al. Essential fatty acids in the plasma phospholipids of patients with atopic eczema. Br J Derm 1984;110:643.
6Horrobin DF. Essential fatty acids in clinical dermatology. J Am Acad Dermatol 1989;20:1045–53.

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