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Preheat oven to 400 degrees F.
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In large bowl, drizzle butternut squash with extra virgin olive oil. Season with garlic powder, smoked paprika, chipotle powder, ground cumin, salt and pepper. Toss to evenly coat.
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On non-stick baking sheet, spread butternut squash in single layer. Bake 20-25 minutes, or until squash is tender. Set aside until cool enough to handle.
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In small bowl, combine yogurt and chipotle peppers/salsa until well combined. Refrigerate to keep chilled.
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On flat work surface, spread out tortilla. Working on half, sprinkle ½ cup shredded mozzarella, evenly distribute roasted butternut squash, then top with ½ cup spinach. To close, fold over empty half tortilla. Repeat with three more tortillas.
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Working one tortilla at a time, in non-stick pan, cook quesadilla over medium heat for approximately 6 minutes – or until cheese is melted, spinach is wilted and tortillas are crispy. Flip each halfway through. (Tip: Place each quesadilla on baking sheet in oven at low temperature to keep warm while cooking remaining quesadillas.)
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Cut each quesadilla into 4 triangles and serve warm with chipotle cream.