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In mixing bowl, combine flour, sugar, salt and baking powder.
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Add frozen butter cubes to dry ingredient mixture, and use hands or a pastry cutter to work butter into flour until you have pea-sized clumps of butter coated in flour.
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In liquid measuring cup, whisk together buttermilk, egg, lime juice and lime zest. Pour mixture into bowl with butter and flour.
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Add blackberries and gently stir with wooden spoon or hands until dough just comes together. (Note: Avoid overmixing to prevent tough scones.)
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Transfer dough to lightly floured work surface and shape into a disc about 8 inches in diameter and 1/2-inch thick. (Note: Dough should be slightly sticky. If dough is dry, add buttermilk 1 Tbsp. at a time. If dough is too wet, add flour. Use floured hands to work with dough.)
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Use bench scraper or sharp knife to divide disc into 8 wedges. Arrange wedges on parchment-lined baking sheet.
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Refrigerate 15 minutes. Preheat oven to 400 degrees F.
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Remove scones from fridge and brush with buttermilk. Bake 20-25 minutes or until golden brown on bottom and cooked through. Remove from oven and cool fully before adding glaze.
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To make glaze, in small bowl, whisk together powdered sugar, milk and vanilla until smooth. For thicker icing, add more sugar 1 Tbsp. at a time. For thinner icing with drizzle consistency, add more milk 1 Tbsp. at a time.
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When scones are cool, drizzle with glaze and serve.