8 Unique Immune System Supplements to Try This Fall

Kiki Powers

by | Updated: September 24th, 2025 | Read time: 4 minutes

Autumn can be a busy time, whether you are adjusting back to a more strenuous work schedule after summer, decompressing from travel, returning to school, etc. Clearly, these kinds of changes can be stressful. If that stress is ongoing, or chronic, it can undermine your wellness, potentially making you more vulnerable to seasonal ailments and other health issues.

Cozy Fall Table Setting with Tea, Leaves & Notebook to Represent Concept of Immune System Supplements for Fall | Vitacost.com/blog

While we can’t always change the stress-causing factors in our lives ─ nor can we avoid all seasonal germs, bacteria and viruses ─ we can make a concerted effort to protect ourselves by maintaining a strong immune system. As one scientist aptly noted, the susceptibility of an individual to viral or bacterial infections is dependent upon immune competence. These innovative immune support supplements can help support your lines of defense, naturally.

Immune System Supplements 

Country Farms Immune Defense Drink

This convenient, all-in-one drink mix combines a powerful blend of immune-supporting ingredients to help bolster your body’s natural defenses. It features a concentrated mix of immunity superfoods including elderberry, cranberry and maqui berry along with alkalizing greens, multi-mushrooms and herbal support. A hydration boost from beet, coconut water and watermelon and a blend of prebiotics and probiotics round out the formula. Simply add a scoop to water for a delicious way to support your daily wellness.

Country Farms Immune Defense Drink

Goli Nutrition Triple Action Immune Gummies

These small but mighty gummies offer a delicious and easy way to support your immune health. The formula is centered on a powerful trio of vitamins C and D along with zinc, nutrients that help maintain healthy immune function. It’s also enhanced with a unique elderberry extract and a botanical blend of echinacea, turmeric and ginger, which have been traditionally used to support overall wellness. These vegan, gluten-free and gelatin-free gummies are a simple addition to your daily routine, making it easy to put your best foot forward.

Goli Nutrition Triple Action Immune Gummies

Rainbow Light Counter Attack Immune Support

This powerful, vegan formula delivers vitamin C and zinc along with three targeted herbal blends to support a healthy immune response. The formula features an Immune Guard Clear Complex with a wide-ranging blend of botanicals like yerba santa and echinacea purpurea. A Mobilizing Herbal Complex with elderberry and andrographis rounds out this supplement, which is designed to help you support your body’s natural defenses and thrive during seasonal changes.

Rainbow Light Counter Attack

Zand Immune Fast – Zesty Orange

Designed for on-the-spot immunity, these chewable tablets offer a powerful combination of key nutrients to help support healthy immune function. The unique formula contains EpiCor, a cinically studied substance that supports immune cell activity, along with vitamin C, zinc and echinacea. These tablets are naturally sweet, sugar-free and easy to take, making them an ideal choice for anyone who needs to be at the ready.

Zand Immune Fast

Gaia Herbs Black Elderberry immune Support

Support your body’s natural defenses with this powerful herbal blend. The formula features black elderberry, a fruit rich in antioxidant flavonoids, which are thought to support a healthy immune function. Organic acerola fruit extract is also included for additional wellness benefits. This vegan supplement provides a simple way to incorporate the goodness of herbs into your daily routine.

Gaia Herbs Black Elderberry Immune Support

Florastor Advanced Daily Probiotic and Immune Support

Support your gut and your immune system with this daily probiotic supplement. It’s fomulated with the unique probiotic yeast Saccharomyces boulardii CNCM I-745, which helps to support digestive balance and healthy production of Immunoglobulin A, a key antibody for a healthy immune system. The formula is also fortified with zinc, vitamin C and vitamin D3 for comprehensive wellness benefits.

Florastor Advanced Daily Probiotic & Immune Support with Zinc Vitamin C & D3

OM Organic Mushroom Nutrition Supplement Powder

This blend of seven unique species of organic mushrooms offers a synergy of natural wellness support and may promote a positive inflammation response. Keep your system bolstered naturally with powerful beta glucans, digestive enzymes, fiber, prebiotics, antioxidants and other important nutrients. Simply add a teaspoon to your daily juice or smoothie. You can also blend into soup or broth before serving.

OM Organic Mushroom Nutrition Supplement Powder - Immune | Vitacost.com/blog

Zahler ImmuniKid Children’s Immune Support

This supplement is a kid-friendly, all-natural formula designed to suport a child’s immune system. It features a blend of vitamin C, vitamin D3 and zinc, all of which are documented for their immune-supporting properties. Additionally, the formula is infused with a proprietary blend of berries, including goji, aronia and schisandra fruit, which provide antioxidants and vitamin C. The product is grape-flavored and free of drugs, artificial sweeteners and high fructose corn syrup.

Zahler ImmuniKid Children's Immune Support Grape

Again, germs, bacteria and viruses will continue to be prevalent in life, as will high stress levels for many people. It therefore pays to do what you can to bolster your own natural protection as much as possible. The best defense is a good offense. Here’s to your health!

These statements have not been approved by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent disease.