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Jarrow Formulas Bone & Joint SAMe -- 400 mg - 60 Tablets

Jarrow Formulas Bone & Joint SAMe
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Jarrow Formulas Bone & Joint SAMe -- 400 mg - 60 Tablets

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Jarrow Formulas Bone & Joint SAMe Description

  • New pH-Sensetive, Food Grade Enteroguard® coating
  • S-Adenosyl Methionine
  • 400 mg (net yield) SAM-e from 800 mg SAM-e Tosylate Disulfate
  • Highest Concentration of Active S,S Form
  • Promotes:
    • Joint Strength
    • Liver Detoxification
    • Mood and Brain Function
  • Enteric-Coated Tablets
  • Gluten Free
  • Vegan/Vegetarian

Jarrow Formulas® SAM-e 400 provides a full 400 mg SAM-e (net yield) from 800 mg of SAM-e tosylate disulfate. SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.


Contains More of the Active S,S Form

Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAM-e is made naturally by microbiological fermentation and then specially processes without chemical solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.


SAM-e has been clinically shown to have the following benefits:


Joint Strength

SAM-e supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAM-e metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.


Brain Metabolism

SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopramine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).



SAM-e supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transerase), which are substances important for liver function, including phase II detoxification.


EnteroGuard® is a proprietary cellulose-based, food-grade, pH-sensitive enteric coating that resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.


Usage: take 1 tablet per day on an empty stomach or as directed by your qualified healthcare professional.

Free Of
Wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts
Serving Size: 1 Tablet
Servings per Container: 60
Amount Per Serving% Daily Value
S-Adenosyl Methionine (from 800 mg of SAM-e tosylate disulfate)400 mg*
*Daily value not established.
Other Ingredients: Cellulose, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, mannitol, sodium starch glycolate, and an enteric coating (modified cellulose, magnesium silicate, triethyl citrate and riboflavin).

Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using this product. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e. Do not use if pregnant or nursing. Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.

The product you receive may contain additional details or differ from what is shown on this page, or the product may have additional information revealed by partially peeling back the label. We recommend you reference the complete information included with your product before consumption and do not rely solely on the details shown on this page. For more information, please see our full disclaimer.
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4 Ways That Laughter Benefits Your Health

A good belly laugh does wonders for your mood—but did you also know that it has a remarkable impact on your health? Below are four benefits of laughter that confirm that laughter trumps apples as the best way to keep the doctor away.

Two Women Enjoying the Benefits of Laughter and Each Other's Company While Looking at Pictures on Phone |

1. Busts stress

Laughter functions as a stress buster by shutting down the release of stress hormones like cortisol. It also triggers the production of feel-good neurochemicals like dopamine, which have all kinds of calming, anti-anxiety benefits.

2. Relieves pain

Laughter enhances your intake of oxygen-rich air, stimulates your heart, lungs and muscles, and increases the endorphins that are released by your brain. It can also ease pain by causing the body to produce its own natural painkillers.

3. Strengthens relationships

Laughter is central to relationships. Several studies point to shared laughter as a marker of relationship well-being. The amount of laughter a couple shares is connected to how close they feel and how supported they feel by the relationship. In other words, the more laughter a couple reports, the more favorably they rate their relationship.

4. Reduces blood pressure

one of the most dangerous side effects of stress is high blood pressure (hypertension), which is also a huge risk factor for heart disease and stroke. However, since stress and laughter can’t coexist, researchers have investigated whether laughter can bring blood pressure down. Several studies show a reduction of blood pressure after laughter, such as a 2017 study in the Journal of Dental and Medical Research, where patients exposed to “humor therapy” in the form of CDs of comic shows saw a decrease in blood pressure.

So now that you know that laughter has serious health benefits, how do you boost your chuckle quotient? Can you improve your sense of humor by working it like a muscle? As it turns out, you can. These three suggestions can make humor part of your daily repertoire of experiences.

Seek out humor

Whether its comedy videos, memes, cartoons or satire, actively seek out things that make you laugh. Cut out cartoons and put them on your fridge or hang them in your office. Make humor a priority—without getting to earnest about it. Find ways to cast a comical light on even the most serious situations.

Laugh at yourself

There’s nothing like being the butt of your own jokes to spread the levity. Being able to laugh about unfortunate events means you are able to tap into a wider perspective and get much needed distance on the problem.

Laughter loves company

One oft-cited study found that you’re 30 times more likely to laugh around other people than when you are by yourself. Invite friends over to watch stand-up comedy or simply get silly with your friends. Plenty of board games are designed to elicit humor. You can also make sure you have a good joke up you sleeve to bring a twinkle to someone else’s eye—and you may end up laughing at their enjoyment in the bargain.

Finally, I would like to conclude on a humorous note. Have you heard the one about why the buddha couldn’t vacuum under the sofa? Answer: He didn’t have any attachments. That’s the power of humor—to loosen our attachment to our plight so we can accept life’s twists with amusement.

Keep the good times rolling! Try these solutions to support a healthy mood: 

Vitacost Synergy Mood Plus† with 5-HTP & St. John's Wort  |

Nature's Plus Herbal Actives NutriZAC® Mood Food |

Country Life Omega 3 Mood™  |

Vitacost is not responsible for the content provided in customer ratings and reviews. For more information, visit our Terms of Use.

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